Elevated Senescence Markers in Developing Trisomy 21 Human Lungs.

Human chromosomal anomalies, notably trisomies, disrupt gene expression, leading to diverse cellular and organ phenotypes. Increased cellular senescence (SEN) and oxidative stress in trisomies have gained recent attention. We assessed SEN, senescence-associated secretory phenotype (SASP) and oxidative stress on trisomy 13, 18, and 21 (T13, T18, T21) human fetal lung tissues and isolated primary human fetal lung fibroblasts.

Functional role of the long noncoding RNA X-inactive specific transcript in leiomyoma pathogenesis.

Objective: To determine the expression and functional roles of a long noncoding RNA (lncRNA) X-inactive specific transcript (XIST) in leiomyoma.

Design: Experimental study.

Setting: Academic research laboratory.