Publications by authors named "Anika Hirche"
Article Synopsis
- Tauopathies, including Alzheimer's disease, are big health problems for older people, and we need to better understand how they work to help find treatments.
- Scientists are working on new therapies that focus on tau, a protein related to these diseases, but they need to know more about how these diseases affect the brain and how to make better medicines.
- A new 3D cell model was created to study tauopathies in a better way, allowing researchers to watch how brain cells change in real-time, making it easier to test potential treatments.
Herewith we developed a novel 3D in vitro Alzheimer's disease (AD) model, based on the human neuroblastoma cell line SH-SY5Y, which is well differentiated without the application of any agents. Furthermore AD-like pathological neurodegeneration can be induced by okadaic acid (OA) mediated hyperphosphorylation of the microtubule associated protein tau. Moreover, we established stable "rapid tauopathy cell lines" expressing additional EGFP-fused (enhanced green fluorescent protein) wildtype or a pathology-promoting mutant tau variant (P301L) by lentiviral transduction.
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