[Effect of industrial noise and ototoxic antibiotics on ear function in man].

Fifty workers of the 166 ones examined were occupationally exposed to noise; 26 of them were treated with ototoxic antibiotics. Workers of treated with antibiotics most often (69.2%) developed deterioration of acoustic function.

[Reasons for the use of mydocalm in the prevention and treatment of antibiotic-induced sensorineural hearing loss].

The applicability of mydocalm for the prevention and therapy of hypoacusis caused by kanamycin, an antibiotic of the aminoglycoside series, was investigated in animal (guinea-pig) experiments. The changes in nucleic acids and nuclear size of the spiral organ were used as parameters. Hearing loss as shown by the lack of Preyer's reflex developed in response to kanamycin injected at a dose of 50 mg/kg/day for 14 days.

[Receptor epithelium of the vestibular apparatus and cochlea in exposure to acceleration and noise].

The method for isolating and treating the vestibular and cochlear compartments of the inner ear was developed. Also, the procedure of histological treatment of temporal bones was modified. The pathogenesis of vestibulo-cochlear disorders due to acceleration and noise was investigated using histology, electron microscopy and histochemistry methods.

[Ultrastructural changes in the receptor portion of the vestibular apparatus in response to noise].

The experiments have been performed on 24 guinea pigs (48 labyrinthes), 6 of them--control and 18 have been subjected to noise (one octava) with the average geometrical in diaposone of 2,000 Hz, at intensity level 100 dB. Six animals are subjected to a single effect for 6 h and 12--to repeated effect during 6 days running, 4-6 h daily. Isolation of both the vestibular and the cochlear parts of the membranous labyrinth is performed simultaneously.

The structural and functional organization of the vestibular apparatus of rats exposed to weightlessness for 20 days on board the Sputnik "Kosmos-782".

This investigation of the vestibular apparatus of rats exposed for 20 days to weightlessness on board an earth satellite and to acceleration during take-off and landing has revealed a set of changes in the structural and functional organization, such as adjoinment of the otolith to the utricle receptor surface and peripheral localization of the nucleoli inside the receptor cells' nuclei. Destruction of some receptor cells, apparently due to increased swelling of the vestibular apparatus tissue and alteration of the shape and structure of the otoconia were observed. In the horizontal crista, detachment of the cupula took place.

[Methods of histological treatment of the labyrinth].

The otic labyrinth presents one of the most difficult objects for histological investigations as it is situated in the thick layer of the temporal bone and has a very complex structure. At the same time, a method for treating this object is not given in general hand-books on pathological techniques. The methods for histological treatment of the otic labyrinth elaborated by Wittmaack and later on modified are presented in the article.