Publications by authors named "Ania A Baranowska-Clarke"
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.
David Adlam Takiy-Eddine Berrandou Adrien Georges Christopher P Nelson Eleni Giannoulatou Ania A Baranowska-Clarke
Nat Genet
June 2023
Article Synopsis
- * A large study identified 16 genetic risk factors for SCAD, highlighting potential genes involved in blood vessel function and the physical structure of arteries.
- * Some genetic variants linked to SCAD show opposing effects on CAD, suggesting that while both diseases share certain biological links, they operate through different pathways; high blood pressure was also found to possibly contribute to SCAD risk.
Aims: Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndromes and in rare cases sudden cardiac death (SCD). Connective tissue abnormalities, coronary inflammation, increased coronary vasa vasorum (VV) density, and coronary fibromuscular dysplasia have all been implicated in the pathophysiology of SCAD but have not previously been systematically assessed. We designed a study to investigate the coronary histological and dermal collagen ultrastructural findings in SCAD.
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