Publications by authors named "Anh-Thy Huynh"
Clinical reports of Zika Virus (ZIKV) RNA detection in breast milk have been described, but evidence conflicts as to whether this RNA represents infectious virus. We infected post-parturient AG129 murine dams deficient in type I and II interferon receptors with ZIKV. ZIKV RNA was detected in pup stomach milk clots (SMC) as early as 1 day post maternal infection (dpi) and persisted as late as 7 dpi.
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- Research indicates that prior immunity to Dengue virus (DENV) can influence outcomes of Zika virus (ZIKV) infection during pregnancy.
- In studies with pregnant mice, those immune to DENV showed normal fetal development after ZIKV exposure, while non-immune mice experienced fetal loss.
- The presence of DENV-specific CD8 T cells plays a crucial role in reducing ZIKV infection levels in the placenta and fetuses, suggesting potential strategies for ZIKV vaccine development.