Three new α-glucosidase inhibitors from aqueous extract of leaves: isolation, characterisation, and kinetic study.

α-Glucosidase inhibitory assay-guided isolation of the aqueous extract from leaves afforded three new compounds named cannabisaldehyde (), cannacone A (), and canniprene C (), along with eight previously known compounds (-, ). The structures of new compounds were determined through extensive analysis of various spectroscopic data. Of isolated compounds, cannacone A () demonstrated most potent inhibition against maltase and sucrase with IC values of 80.

A new furanonapthoquinone from the stems of .

α-Glucosidase inhibitory assay-guided purification of L. stems yielded a new compound named 5-acetoxyfuranonapthoquinone () along with nineteen known compounds (-). The structures of the isolated compounds were elucidated by the analysis of multiple spectroscopic data.

Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery.

Porous nanosilica (PNS) has been regarded as a promising candidate for controlled delivery of anticancer drugs. Unmodified PNS-based nanocarriers, however, showed a burst release of encapsulated drugs, which may limit their clinical uses. In this report, PNS was surface conjugated with adamantylamine (ADA) via disulfide bridges (-SS-), PNS-SS-ADA, which was further modified with cyclodextrin-poly(ethylene glycol) methyl ether conjugate (CD-mPEG) to form a core@shell structure PNS-SS-ADA@CD-mPEG for redox triggered delivery of doxorubicin (DOX), DOX/PNS-SS-ADA@CD-mPEG.