HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient.

Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab.

Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence hybridization and dual hybridization (ISH).