Publications by authors named "Angus de Wilton"
Background: To report on the implementation and outcomes of a virtual ward established for the management of mpox during the 2022 outbreak, we conducted a 2-center, observational, cross-sectional study over a 3-month period.
Methods: All patients aged ≥17 years with laboratory polymerase chain reaction-confirmed monkeypox virus managed between 14 May and 15 August 2022, at the Hospital for Tropical Diseases at University College London Hospitals National Health Service (NHS) Foundation Trust and sexual health services at Central North and West London NHS Foundation Trust, were included. Main outcomes included the proportion of patients managed exclusively on the virtual ward, proportion of patients requiring inpatient admission, proportion of patients with human immunodeficiency virus, and duration of lesion reepithelialization.
Article Synopsis
- Researchers analyzed 93 pediatric and adult COVID-19 patients alongside healthy controls to understand why COVID-19 is milder in children.
- They found heightened interferon-activated cells in the airways of healthy children, leading to stronger immune responses that may limit viral replication.
- The study suggests that children's immune responses differ significantly from adults, with a unique pattern of lymphocyte activity and interferon signaling that contributes to less severe illness.
Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16C1QA/B/C) that sequester platelets and were predicted to replenish the alveolar macrophage pool in COVID-19.
View Article and Find Full Text PDFBackground: Neuroschistosomiasis is a severe complication of schistosomiasis, triggered by the local immune reaction to egg deposition, with spinal cord involvement the most well recognised form. Early treatment with praziquantel and high dose steroids leads to a reduction of neurological sequelae. The rarity of this condition in returning travellers to high income countries can result in delayed diagnosis and treatment.
View Article and Find Full Text PDFObjectives: To describe a cohort of self-isolating healthcare workers (HCWs) with presumed COVID-19.
Design: A cross-sectional, single-centre study.
Setting: A large, teaching hospital based in Central London with tertiary infection services.