Publications by authors named "Angus T McLure"
Article Synopsis
- Researchers analyzed genomic and epidemiological data to compare the population structure of a foodborne pathogen in Australia and New Zealand, two countries with strong trade and cultural connections.
- The study found significant differences in the most common sequence types (STs) between the countries, with many STs being unique to each one, and over half of the STs represented by only a single isolate.
- Multidrug-resistant genotypes were rare (0.8%) and not found in poultry, but a specific resistant strain was prevalent in New Zealand, highlighting the local origins of the pathogen and minimal genetic overlap between human and poultry strains in both countries.*
is a globally important pathogen with well-studied risk factors, but the burden of risk factors has not been quantified. We quantified the cost of illness attributable to specific domestic risk factors for and in Australia. We used data from a 2018-2019 case-control study to estimate odds ratios and attributable fractions for risk factors.
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- Campylobacter spp. are a leading cause of bacterial gastroenteritis in Australia, often linked to contaminated meat, with a study exploring the relationship between genomic virulence characteristics and the severity of the illness.
- The research included 571 campylobacteriosis cases, revealing that symptoms typically last about 7.5 days and vary in severity based on age and pre-existing health conditions, with older patients exhibiting milder symptoms but higher hospitalization rates.
- Although the study found many virulence genes present in the bacteria, they did not correlate with illness severity; instead, age and comorbidities were identified as the primary factors influencing health outcomes.
Background: We aimed to identify risk factors for sporadic campylobacteriosis in Australia, and to compare these for Campylobacter jejuni and Campylobacter coli infections.
Methods: In a multi-jurisdictional case-control study, we recruited culture-confirmed cases of campylobacteriosis reported to state and territory health departments from February 2018 through October 2019. We recruited controls from notified influenza cases in the previous 12 months that were frequency matched to cases by age group, sex, and location.