Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut.

Microbial metabolism is a major determinant of antibiotic susceptibility. Environmental conditions that modify metabolism, notably oxygen availability and redox potential, can directly fine-tune susceptibility to antibiotics. Despite this, relatively few studies have discussed these modifications within the gastrointestinal tract and their implication on drug activity and the off-target effects of antibiotics in the gut.