Publications by authors named "Angiza Shahim"
Aims: The detailed sub-categories of death and hospitalization, and the impact of comorbidities on cause-specific outcomes, remain poorly understood in heart failure (HF) with preserved ejection fraction (HFpEF). We sought to evaluate rates and predictors of cardiovascular (CV) and non-CV outcomes in HFpEF.
Methods: The Karolinska-Rennes study was a bi-national prospective observational study designed to characterize HFpEF (ejection fraction ≥45%).
Article Synopsis
- The study aimed to analyze the causes of death in heart failure patients with different ejection fractions: preserved (HFpEF), mildly reduced (HFmrEF), and reduced (HFrEF).
- Data from around 100,584 patients over 21 years showed that cardiovascular causes were the leading reason for death across all ejection fractions, but HFpEF patients had a higher risk of dying from non-cardiovascular issues.
- Ischemic heart disease and cancer were identified as the most common causes of cardiovascular and non-cardiovascular deaths, respectively, with the risk of non-cardiovascular death increasing as ejection fraction improved.
Article Synopsis
- This study focused on the prevalence, characteristics, and outcomes of patients with heart failure (HF) who have mitral regurgitation (MR) and/or tricuspid regurgitation (TR).
- Among 11,298 patients studied, a significant majority (67%) had no MR/TR, while 17% had isolated MR, 5.5% had isolated TR, and 11% had both conditions.
- The findings indicated that those with HFpEF had a higher likelihood of isolated TR but were at a greater risk for poor outcomes, highlighting the need for targeted management in patients with isolated TR.
Article Synopsis
- The study aimed to evaluate how common and impactful moderate to severe aortic valve disease (AVD) is in patients with heart failure (HF), focusing on various types such as aortic stenosis (AS) and aortic regurgitation (AR).
- Data from over 15,000 HF patients indicated that approximately 10% had AVD, with AS and mixed AVD being more frequent in those with preserved ejection fraction, while AR was present in all HF types.
- AS and mixed AVD were linked to a higher risk of cardiovascular death and HF-related hospitalizations within 12 months, indicating their significant impact on patient outcomes compared to AR.
Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with cardiovascular (CV) and non-CV events, but long-term risk is poorly studied. We assessed incidence and predictors of the long-term CV and non-CV events.
Methods And Results: Patients presenting with acute HF, EF ≥ 45%, and N-terminal pro-brain natriuretic peptide > 300 ng/L were enrolled in the Karolinska-Rennes study in 2007-11 and were reassessed after 4-8 weeks in a stable state.
Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) has poor long-term prognosis. We assessed rates and predictors of outcome 10 years after an acute episode of HF.
Methods And Results: The Karolinska-Rennes (KaRen) study enrolled HFpEF patients with acute HF, ejection fraction ≥ 45%, and N-terminal pro-brain natriuretic peptide > 300 ng/L in 2007-11.