Oxygen distribution in the rabbit eye and oxygen consumption by the lens.

Purpose: Excessive exposure to oxygen has been proposed to be a risk factor for nuclear cataracts. For a better understanding of the metabolism of oxygen in the eye, oxygen distribution was mapped in the intraocular fluids, and the rate of oxygen consumption by the lens in rabbits breathing different levels of oxygen was calculated.

Methods: Young albino rabbits were anesthetized, intubated, and exposed to normoxic, hypoxic, or hyperoxic conditions.

Maintaining the surgical research facility: the role of the surgical technician.

Building a well-equipped surgical facility is only half the battle. By ensuring that these facilities and their equipment are kept clean and well maintained, and that clear and thorough documentation is kept, research staff can protect both the quality of their work and the well-being of their animal patients.

Mechanism of lonidamine inhibition of the CFTR chloride channel.

1. The cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel is blocked by a broad range of organic anionic compounds. Here we investigate the effects of the indazole compound lonidamine on CFTR channels expressed in mammalian cell lines using patch clamp recording.