Publications by authors named "Angie H Fares"

Article Synopsis
  • Infantile-onset Pompe disease (IOPD) is a serious condition caused by a deficiency in the enzyme acid alpha-glucosidase, leading to severe heart and muscle problems that can be fatal within the first 2 years without treatment.
  • Enzyme replacement therapy (ERT) with alglucosidase-alfa is crucial for treatment, but its success can be affected by factors like the patient's immune response and CRIM status.
  • A case study of CRIM-negative twins treated with high-dose ERT and immune tolerance induction showed significant improvements in cardiac function and biomarkers, highlighting the importance of early intervention in managing IOPD.
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Background: The objective of this study was to explore the impact of COVID-19 on the lived experiences of patients with cancer in Lebanon.

Methods: We adopted a descriptive phenomenological approach. We included adults who had been diagnosed with cancer before the pandemic and undergoing treatment at the American University of Beirut Medical Centre.

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NETosis, a novel form of neutrophil-related cell death, acts as a major regulator of diabetes and diabetes-associated complications. In this review, we show that the extrusion of neutrophil extracellular traps, termed NETs, plays an important role in the pathogenesis of type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and diabetes-induced complications. In T1DM, β-cell death induces the sequestration of neutrophils in the pancreas and seems to be correlated with increased NETosis.

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In light of the most challenging public health crisis of modern history, COVID-19 mortality continues to rise at an alarming rate. Patients with co-morbidities such as hypertension, cardiovascular disease, and diabetes mellitus (DM) seem to be more prone to severe symptoms and appear to have a higher mortality rate. In this review, we elucidate suggested mechanisms underlying the increased susceptibility of patients with diabetes to infection with SARS-CoV-2 with a more severe COVID-19 disease.

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