Prospective observation of Clostridium histolyticum collagenase for the treatment of Dupuytren's disease in 788 patients: the Austrian register.

Introduction: Since March 2011, the microbial collagenase of Clostridium histolyticum (Xiapex®, Swedish Orphan Biovitrum AB, Stockholm, Sweden) has become available in the European Union for treatment of Dupuytren's disease. The purpose of this study was to evaluate potential safety risks of Xiapex® and to contribute to a better understanding for its use.

Methods: A prospective, non-interventional, observational study using Xiapex® for Dupuytren's disease named XIANIS was conducted between 1.

Restoring independency with an osteochondral graft of the navicular for coronoid process reconstruction.

Introduction: The coronoid is a crucial element for elbow stability. In case of posttraumatic instability or reduced range of motion, a complex reconstruction might be necessary.

Case: We present the case of a polytraumatized patient with complex upper extremity injury and initial poor outcome.

[Avocado/soybean unsaponifiables in the treatment of knee and hip osteoarthritis].

Avocado/soybean unsaponifiables (ASU) is an extract prepared from avocado and soybean oil. The product has been approved as a prescription drug in France for several years and has now been introduced in Denmark as a food supplement. ASU has been examined in vitro and in animal studies that have showed an anti-inflammatory effect and a stimulatory effect on proteoglycan synthesis in chondrocytes.

[Glucosamine and chondroitin sulfate in the treatment of arthritis].

Glucosamine and chondroitin sulphate are naturally occurring substances used by an increasing number of Danish patients with arthritis, although neither of the compounds has been approved for sale in Denmark. Both substances can be taken by mouth and have no known significant side effects. Glucosamine and chondroitin sulphate have been examined in laboratory and animal experiments, and in several clinical studies, which have shown some effect on the symptoms of early or moderate arthritis.

Injectable calcium phosphate bone cement Norian SRS for the treatment of intra-articular compression fractures of the distal radius in osteoporotic women.

Background: Distal radius fracture often presents a metaphyseal void which is more extended in elderly, osteoporotic patients. Bone graft and bone substitutes are reported to be beneficial in maintaining metaphyseal reduction.

Methods: We performed a prospective study on 52 menopausal, osteoporotic women with unstable intra-articular distal radius fractures to compare the outcome of percutaneous pinning and immobilisation in a cast for 6 weeks with that using injectable calcium phosphate bone cement (Norian Skeletal Repair System, SRS) to supplement pin and screw fixation and immobilisation in a cast for 3 weeks.