Cord blood unit (CBU) transplantations can achieve similar success rates to fully matched transplants if they are mismatched for only one HLA antigen, as long as this mismatch is a noninherited maternal antigen (NIMA).
Virtual matching significantly increases the available options for patients, with findings showing that it could provide an additional 20% of patients with a 6/6 virtual match.
Exploring maternal HLA phenotypes could enhance the efficacy and cost-effectiveness of CBU transplants by increasing the number of viable matches for patients in need.