Publications by authors named "Angelo C"

Most public health practitioners and researchers in Australia acknowledge the poorer health and wellbeing of Aboriginal and Torres Strait Islanders peoples relative to non-Indigenous Australians; some work with Aboriginal and Torres Strait Islander communities; however, few acknowledge the role that public health itself has played in the plight of Aboriginal and Torres Strait Islanders peoples throughout Australia's colonial history. In this essay, we - Aboriginal, Torres Strait Islander, and non-Indigenous scholars at the Sydney School of Public Health (SSPH) - argue that truth-telling, which is critical for reconciliation, can only truly begin in Australian public health circles when we listen to the stories and truths of Aboriginal and Torres Strait Islander peoples as it relates to the colonial history of public health in Australia. Herein we give a brief outline of that history and provide some recommendations on ways forward; we also describe the successes and failures at SSPH in hopes that our story can help the broader Australian public health community on their truth-telling journeys.

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Circadian rhythms are a mechanism by which species adapt to environmental variability and fundamental to understanding species behavior. However, we lack data and a standardized framework to accurately assess and compare temporal activity for species during rapid ecological change. Through a global network representing 38 countries, we leveraged 8.

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Magnetic Tunnel Junction-based molecular spintronics devices (MTJMSDs) hold great potential for integrating paramagnetic molecules with ferromagnetic electrodes, creating a diverse array of metamaterials with novel magnetic behaviors. Understanding interactions, especially between molecules and electrode materials, is essential to advancing this field. In this study, we used Monte Carlo simulation (MCS) to examine the influence of Dzyaloshinskii-Moriya interaction (DMI) on the MTJMSDs.

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In recent years, there has been a significant increase in oil exploration and exploitation activities, resulting in spills that pose a severe threat to the environment and public health. The present work aims to develop a method to detect and classify hydrocarbon-contaminated soils that is useful for analyzing contaminated sites. The method combines machine learning algorithms with data obtained via the laser-induced breakdown spectroscopy (LIBS) technique.

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Introduction: In the so-called "new career era," career transitions and employability have attracted growing attention. For elite athletes, the Dual Career experiences may be regarded as a protective factor during various career transitions, with the end-of-career transition being closely linked to employability. This contribution aims to explore the dual career paths of athletes through the lens of graduate employability, as perceived by the individuals themselves.

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Chimeric antigen receptor T (CAR T) cell therapies have emerged as a valuable treatment modality for patients with plasma cell disorders. As the population of patients receiving CAR T therapies grows, the identification and management of associated rare toxicities become increasingly crucial. This study aims to identify safety signals associated with commercial anti-B-cell maturation antigen (BCMA) CAR T therapies using the Food and Drug Administration Adverse Event Reporting System (FAERS).

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Background: Limited evidence exists around authentic activities that can positively influence students' knowledge of and appreciation for the First Nations peoples' culture, impacts of colonisation and other determinants of health. A renewed Indigenous Health curriculum provided us with an opportunity to implement a cultural immersion for medical students to enhance their cultural awareness and competency.

Approach: Our approach towards the design and evaluation of cultural immersion was guided by three key frameworks-a strengths-based approach towards curriculum design, Indigenous ways of knowing and being and immersions as transformative pedagogy.

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Microbial biofilm formation on medical devices paves the way for device-associated infections. is one of the most common strains involved in such infections as it is able to colonize numerous devices, such as intravenous catheters, prosthetic joints, and heart valves. We previously reported the antibiofilm activity against of pentadecanoic acid (PDA) deposited by drop-casting on the silicon-based polymer poly(dimethyl)siloxane (PDMS).

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Registered nurses in the operating room require specialized competencies that surpass basic educational training. Existing national and international documents attempt to outline these competencies but often lack comprehensive details. To address this, a repertoire of technical and professional competencies for operating room nurses, aligned with European and National Qualifications Frameworks, is proposed.

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Glioblastoma (GBM) is the most common malignant primary brain cancer that, despite recent advances in the understanding of its pathogenesis, remains incurable. GBM contains a subpopulation of cells with stem cell-like properties called cancer stem cells (CSCs). Several studies have demonstrated that CSCs are resistant to conventional chemotherapy and radiation thus representing important targets for novel anti-cancer therapies.

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Workplaces cause employees to adopt sedentary behaviors for most of their daytime, negatively impacting psychophysical health. A new office concept (UP150) was designed to reduce sedentary behaviors at work through architectural changes, proactive technologies, and wellness coaches (education to active lifestyles). The present study examined the effects of the UP150 concept, previously investigated in dedicated workspaces, with a 12-month longitudinal trial in a real worksite environment.

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Patients affected by glioma frequently experience epileptic discharges; however, the causes of brain tumor-related epilepsy (BTRE) are still not completely understood. We investigated the mechanisms underlying BTRE by analyzing the effects of exosomes released by U87 glioma cells and by patient-derived glioma cells. Rat hippocampal neurons incubated for 24 hours with these exosomes exhibited increased spontaneous firing, while their resting membrane potential shifted positively by 10-15 mV.

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Iron is a key micronutrient essential for various essential biological processes. As a consequence, alteration in iron concentration in seawater can deeply influence marine biodiversity. In polar marine environments, where environmental conditions are characterized by low temperatures, the role of iron becomes particularly significant.

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Article Synopsis
  • Hemosiderotic/aneurysmal variant of dermatofibroma is a rare type of skin tumor that can be misdiagnosed as malignant cancers, such as melanomas or sarcomas.
  • The report details a case of a 7.6cm subcutaneous tumor in a 53-year-old woman, highlighting its unique imaging characteristics and histological features, including the presence of hemosiderin pigment and pseudovascular spaces.
  • Despite the tumor being large and not having clear surgical margins, the patient showed no signs of local recurrence or metastasis after its removal.
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In the current knowledge-based economy, the abilities of the national research system are a key driver of the country's competitiveness and socio-economic development. This paper compares the scientific standing of the OECD countries and eight other relevant economies. We use a bibliometric indicator of research performance, applied first at the individual level.

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Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, mostly due to the high rate of distant dissemination. However, growing evidence shows that isolated lung recurrence or metastases (ILM) from PDAC are not only less common, but also correlated with a better prognosis. Lung-only recurrence after surgery occurs later in time and is associated with more favorable prognostic characteristics of the primary tumor.

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Knee osteoarthritis is the most prevalent type of osteoarthritis. Patients frequently encounter pain triggered by movement that evolves into impaired joint function. Needing persistent rest or having night-time pain signifies advanced disease.

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Redundant tumor microenvironment (TME) immunosuppressive mechanisms and epigenetic maintenance of terminal T cell exhaustion greatly hinder functional antitumor immune responses in chronic lymphocytic leukemia (CLL). Bromodomain and extraterminal (BET) proteins regulate key pathways contributing to CLL pathogenesis and TME interactions, including T cell function and differentiation. Herein, we report that blocking BET protein function alleviates immunosuppressive networks in the CLL TME and repairs inherent CLL T cell defects.

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Unlabelled: Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within the tumor microenvironment (TME) driving activation of NFκB signaling and the unfolded protein response (UPR). Malignant cells have higher basal levels of UPR posing a unique therapeutic window to combat CLL cell growth using pharmacologic agents that induce accumulation of misfolded proteins. Frontline CLL therapeutics that directly target BCR signaling such as Bruton tyrosine kinase (BTK) inhibitors (e.

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Second primary malignancies were reported in 536 of 12 394 (4.3%) adverse event reports following chimeric antigen receptor T-cell therapies in the Food and Drug Administration Adverse Event Reporting System. Myeloid and T-cell neoplasms were disproportionately more frequently reported, warranting further follow-up.

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Background: Breast Cancer (BC) can be classified, due to its heterogeneity, into multiple subtypes that differ for prognosis and clinical management. Notably, triple negative breast cancer (TNBC) - the most aggressive BC form - is refractory to endocrine and most of the target therapies. In this view, taxane-based therapy still represents the elective strategy for the treatment of this tumor.

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Biofilm is accountable for nosocomial infections and chronic illness, making it a serious economic and public health problem. , thanks to its ability to form biofilm and colonize biomaterials, represents the most frequent causative agent involved in biofilm-associated infections of medical devices. Therefore, the research of new molecules able to interfere with biofilm formation has a remarkable interest.

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