Publications by authors named "Angelo Arias-Magnasco"
To assess the longitudinal associations of genomic and exposomic liabilities for schizophrenia, both independently and jointly, with distressing psychotic experiences (PEs) and their persistence in early adolescence. The Adolescent Brain and Cognitive Development Study data from children with European ancestry were used (n=5,122). The primary outcome was past-month distressing PEs at 3-year follow-up.
View Article and Find Full Text PDFBackground And Hypothesis: Persistent distressing psychotic-like experiences (PLE) are associated with impaired functioning and future psychopathology. Prior research suggests that physical activities may be protective against psychopathology. However, it is unclear whether physical activities may interact with genetics in the development of psychosis.
View Article and Find Full Text PDFArticle Synopsis
- Schizophrenia may arise from evolutionary changes that affect how human brains develop, particularly through Human Accelerated Regions (HARs) that enhance neurodevelopmental processes.
- A study compared 128 schizophrenia patients with 115 controls, analyzing polygenic risk scores focused on HARs and their impact on brain structure.
- Results showed that higher polygenic loads from fetal HARs are linked to reduced surface area in specific brain regions in patients, indicating the significance of prenatal transcriptional regulation in schizophrenia risk.