Publications by authors named "Angelita dos Reis Gomes"
Article Synopsis
- - A study analyzed 288 cases of feline sporotrichosis from 2007 to 2018, mainly involving male mongrel cats and adult individuals, aiming to identify risk factors and calculate monthly incidence rates.
- - Statistical findings indicated significant links between prolonged lesion duration and factors like respiratory symptoms and previous treatments, with empirical treatment being a key risk factor for disease progression.
- - The SARIMA model was effective in predicting disease incidence trends, highlighting its importance for monitoring and guiding public health strategies in areas affected by sporotrichosis.
Screening of alkaloids and withanolides isolated from Solanaceae plants for antifungal properties against non-wild type Sporothrix brasiliensis.
J Mycol Med
March 2024
Article Synopsis
- Antifungal resistance is a significant issue in sporotrichosis cases in Southern Brazil, prompting a study of plant compounds from the Solanaceae family for their effectiveness against the fungus Sporothrix brasiliensis.* -
- The study tested multiple compounds, discovering that the steroidal alkaloids solasonine (SSON) and solamargine (SMAR) demonstrated both fungistatic and fungicidal properties, while other compounds were ineffective.* -
- SSON showed a safe cytotoxicity profile on MDBK cells and may be a promising treatment for sporotrichosis in pets, especially in isolates resistant to the commonly used antifungal itraconazole.*
Article Synopsis
- The study investigates the effectiveness of oregano essential oil (EO) and various polar extracts against both itraconazole-susceptible and-resistant dermatophytes, which are fungal infections that affect the skin.
- Among the extracts tested, the decoction (DEC) of oregano showed the strongest antifungal activity, while the EO was effective against all tested fungi, including those resistant to itraconazole.
- The mechanism of action for the EO involves disrupting the fungal cell wall and plasma membrane by binding with ergosterol, and it contains high levels of carvacrol as its active ingredient, marking it as a promising treatment option for dermatophytosis.
Sporotrichosis is a neglected and emerging mycosis caused by the traumatic implantation of Sporothrix propagules into the (sub)cutaneous tissues of humans and animals. We evaluated canine sporotrichosis's clinical-therapeutic, epidemiological profile, and in vitro susceptibility of isolates to itraconazole. The variables were evaluated by a chi-square test.
View Article and Find Full Text PDFA case of subcutaneous phaeohyphomycosis in a dog with an ulcerative lesion on the right limb during a post-operative period of castration was described for the first time. The macroscopic and microscopic characteristics of the fungal colonies growth on the Sabouraud‑dextrose agar were detailed. The fungus was identified as Aureobasidium pullulans on the basis of the phenotypic analysis, which was confirmed by sequencing of the internal transcribed spacers (ITS) region of rDNA.
View Article and Find Full Text PDFArticle Synopsis
- * A hospital team member and six others developed skin lesions after handling a cat with severe injuries, leading to mycological tests that confirmed the presence of Sporothrix brasiliensis.
- * The findings emphasize the need for differential diagnosis and the use of personal protective equipment when dealing with potentially infected animals, especially in regions where the disease is endemic.
Disseminated histoplasmosis in a cat rescued in Fortaleza, Brazil, and successfully treated with itraconazole - First case report identified molecularly.
Med Mycol Case Rep
December 2020
Article Synopsis
- An unneutered female cat with unknown age displayed bloody lesions on its swollen face and had respiratory issues.
- Cytology and cultures revealed yeast within macrophages and confirmed the presence of Histoplasma capsulatum var. capsulatum.
- The cat was treated successfully with oral itraconazole for 120 days, marking the first molecularly confirmed case of feline histoplasmosis in Brazil.*
The treatment of feline sporotrichosis is a challenge for veterinary clinicians since refractory cases may occur, due either to patient and/or to pharmacological management errors or due to the development of antifungal resistance. Thus, we aimed to describe the therapeutic history of feline cases infected by itraconazole-resistant Sporothrix brasiliensis in an endemic region of Southern Brazil. Medical records of cats attended at the Veterinary Clinic Hospital (Pelotas/RS, Brazil) between 2016 and 2017 were reviewed.
View Article and Find Full Text PDFThis work aimed to review the main plants of Lamiaceae family with activity against pathogenic fungi of medical and veterinary interest. Published studies in the main international databases between January 2002 and June 2016 showed that 55 botanical species belonging to 27 genus presented antifungal activity in different forms of extractions, mainly essential oils. Pathogenic fungi of Aspergillus spp.
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- Ear infections in cats are rare, particularly those caused by yeast.
- The report details the first known case of Stephanoascus ciferrii, a type of yeast related to the Candida genus, linked to an ear infection in a cat in Brazil.
- Identification of this yeast was confirmed using the Vitek2 System by BioMerieux.
The susceptibility of Sporothrix schenckii isolates from clinical cases of canine, feline and human sporotrichosis, and from the environment, was evaluated with 4% sodium hypochlorite and 6.6% chlorhexidine digluconate using the broth microdilution, agar diffusion and direct exposure techniques. The minimal inhibitory concentration was smaller than 0.
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