Early and late results of topical diltiazem and bethanechol for chronic anal fissure: a comparative study.

Background/aims: Late efficacy of medical treatment of chronic anal fissure remains controversial due to high recurrence. This study aimed at analyzing safety and efficacy of topical diltiazem and bethanechol regarding healing and symptoms relief, safety, recurrence, and need for surgery.

Methodology: This was a single-center nonrandomized trial.