ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury.

Study Objective: Laboratory evidence indicates that progesterone has potent neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential benefit of administering progesterone to patients with acute traumatic brain injury.

Methods: This phase II, randomized, double-blind, placebo-controlled trial was conducted at an urban Level I trauma center.

Efficacy of an HIV prevention intervention for African American adolescent girls: a randomized controlled trial.

Context: African American adolescent girls are at high risk for human immunodeficiency virus (HIV) infection, but interventions specifically designed for this population have not reduced HIV risk behaviors.

Objective: To evaluate the efficacy of an intervention to reduce sexual risk behaviors, sexually transmitted diseases (STDs), and pregnancy and enhance mediators of HIV-preventive behaviors.

Design, Setting, And Participants: Randomized controlled trial of 522 sexually experienced African American girls aged 14 to 18 years screened from December 1996 through April 1999 at 4 community health agencies.