Effect of defensins-containing eye cream on periocular rhytids and skin quality.

Background: Defensins are peptides shown to activate LGR6 stem cells to stimulate the production of new basal stem cells in the epidermis. Use of topical definsin-containing products has been shown to address signs of global skin aging including decrease of wrinkles and increase of epidermal thickness.

Aims: To investigate the ability of a topical defensin-containing skincare product in improving the structure and function of aging periocular skin using objective and subjective outcome measures.

Transorbital Approach for Improved Access in the Management of Paranasal Sinus Mucoceles.

 Paranasal sinus mucoceles result from obstruction of mucous glands resulting in a cystic fluid collection that expands and encroaches upon surrounding structures. Transnasal endoscopic marsupialization has largely replaced open resection. However, mucoceles located in the orbital region or the lateral frontal sinus continue to be difficult to approach via the transnasal approach alone and often require additional approaches, such as the frontal trephine.

Efficient orbital structures segmentation with prior anatomical knowledge.

We present a fully automatic method for segmenting orbital structures (globes, optic nerves, and extraocular muscles) in CT images. Prior anatomical knowledge, such as shape, intensity, and spatial relationships of organs and landmarks, were utilized to define a volume of interest (VOI) that contains the desired structures. Then, VOI was used for fast localization and successful segmentation of each structure using predefined rules.

An Automated Methodology for Assessing Anatomy-Specific Instrument Motion during Endoscopic Endonasal Skull Base Surgery.

 Describe instrument motion during live endoscopic skull base surgery (ESBS) and evaluate kinematics within anatomic regions.  Case series.  Tertiary academic center.

Complications in facial Mohs defect reconstruction.

Purpose Of Review: To review the recent literature in regards to complications after reconstruction of Mohs defects, outline common pitfalls and to discuss the literature on avoiding complications as outlined per aesthetic subunit.

Recent Findings: Complications in facial Mohs reconstruction commonly consist of infection, wound necrosis and dehiscence, hematoma and suboptimal scarring. However, site-specific complications such as hairline or eyebrow distortion, eyelid retraction or ectropion, nasal contour abnormality, alar retraction, nasal valve compromise, significant facial asymmetry or even oral incompetence must also be considered.

Quantitative Analysis of Transnasal Anterior Skull Base Approach: Report of Technology for Intraoperative Assessment of Instrument Motion.

Objective: To develop a method to measure intraoperative surgical instrument motion. This model will be applicable to the study of surgical instrument kinematics including surgical training, skill verification, and the development of surgical warning systems that detect aberrant instrument motion that may result in patient injury.

Design: We developed an algorithm to automate derivation of surgical instrument kinematics in an endoscopic endonasal skull base surgery model.

Evaluation of segmentation methods on head and neck CT: Auto-segmentation challenge 2015.

Purpose: Automated delineation of structures and organs is a key step in medical imaging. However, due to the large number and diversity of structures and the large variety of segmentation algorithms, a consensus is lacking as to which automated segmentation method works best for certain applications. Segmentation challenges are a good approach for unbiased evaluation and comparison of segmentation algorithms.

Region-Specific Objective Signatures of Endoscopic Surgical Instrument Motion: A Cadaveric Exploratory Analysis.

 The objective of this study was to evaluate region-specific surgical instrument kinematics among novice and experienced surgeons performing endoscopic endonasal skull base surgery.  Cadaveric experimental study.  Tertiary academic center.

Evaluation of a Minimally Disruptive Treatment Protocol for Frontal Sinus Fractures.

Importance: Despite common goals of frontal sinus fracture treatment (restoring forehead contour and creating a safe sinus), there remains significant variability in evaluation and treatment.

Objective: To describe our experience with a minimally disruptive treatment protocol for the treatment of frontal sinus fractures.

Design, Setting, And Participants: Analysis of prospectively collected data from 2010 through 2015 at a level 1 trauma center.

Transorbital endoscopic identification of supernumerary ethmoid arteries.

Background: Anterior and posterior ethmoid arteries supply the paranasal sinuses, septum, and lateral nasal wall. Precise identification of these arteries is important during anterior skull base procedures, endoscopic sinus surgery, and ligation of ethmoid arteries for epistaxis refractory to standard treatment. There is controversy in the literature regarding the prevalence of supernumerary ethmoid arteries.

Computer-Aided Design and 3D Printing to Produce a Costal Cartilage Model for Simulation of Auricular Reconstruction.

Objectives: To demonstrate use of computer aided design and 3D printing in creating simulated costochondral cartilage to practice creation of auricular frameworks. To identify a material that most closely simulates cartilage.

Methods: The costal cartilage of a free floating rib with adjacent synchondrosis was digitally segmented from a CT scan using medical imaging software.

Atlas and feature based 3D pathway visualization enhancement for skull base pre-operative fast planning from head CT.

Minimally invasive neuroendoscopic surgery provides an alternative to open craniotomy for many skull base lesions. These techniques provides a great benefit to the patient through shorter ICU stays, decreased post-operative pain and quicker return to baseline function. However, density of critical neurovascular structures at the skull base makes planning for these procedures highly complex.

Met kinetic signature derived from the response to HGF/SF in a cellular model predicts breast cancer patient survival.

To determine the signaling pathways leading from Met activation to metastasis and poor prognosis, we measured the kinetic gene alterations in breast cancer cell lines in response to HGF/SF. Using a network inference tool we analyzed the putative protein-protein interaction pathways leading from Met to these genes and studied their specificity to Met and prognostic potential. We identified a Met kinetic signature consisting of 131 genes.