Surplus vitamin B use does not reduce fatigue in patients with Irritable Bowel Syndrome or inflammatory bowel disease: A randomized double-blind placebo-controlled trial.

Objective: In non-conventional care, high doses of vitamin B supplementation are used for the treatment of fatigue even in case of normal vitamin B blood levels. We performed a randomized placebo controlled trial to investigate the effect of surplus oral vitamin B supplementation on fatigue in patients with IBS or IBD.

Methods: This randomized double-blind, placebo-controlled trial included 95 out-clinic IBS and IBD patients with deactivating fatigue and normal vitamin B blood levels (≥150 pmol/l) aged 18-65 years.