Publications by authors named "Angeline Buser"
Article Synopsis
- Roux-en-Y gastric bypass (RYGB) surgery can cause post-bariatric hypoglycaemia (PBH) due to changes in glucose handling by the liver.
- A study compared RYGB patients with PBH to healthy controls by tracking glucose and hormone levels after consuming glucose, using advanced imaging techniques.
- Results showed that RYGB patients had distinct glucose and insulin responses, including a quicker rise and fall in glucose levels and lower sensitivity to insulin, but did not have impaired liver glucose uptake or output contributing to PBH.
The liver plays a central role in metabolic homeostasis, as exemplified by a variety of clinical disorders with hepatic and systemic metabolic disarrays. Of particular interest are the complex interactions between lipid and carbohydrate metabolism in highly prevalent conditions such as obesity, diabetes, and fatty liver disease. Limited accessibility and the need for invasive procedures challenge direct investigations in humans.
View Article and Find Full Text PDFBariatric surgery is a highly effective obesity treatment resulting in substantial weight loss and improved glucose metabolism. We hereby aimed to summarize available evidence of the effect of the 2 most common bariatric surgery procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), on dynamic measures of β-cell function (BCF). A systematic search of the literature was conducted in 3 bibliographic databases for studies reporting effects of RYGB and/or SG on BCF assessed using dynamic metabolic perturbation (oral or intravenous bolus stimulation), performed before and 1 year (±3 months) after surgery.
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