Publications by authors named "Angelina Persaud"
Proc Natl Acad Sci U S A
May 2024
Article Synopsis
- Tourette disorder (TD) affects 1 in 160 children, but understanding is limited due to inadequate animal models that replicate the condition's characteristics and behaviors.
- Using CRISPR/Cas9 gene editing, researchers created mouse models with mutations similar to those found in humans with TD, revealing traits like cognitive deficits, sensorimotor gating issues, and increased repetitive behaviors, particularly in females.
- Treatment with aripiprazole improved certain behaviors, while unsupervised machine learning highlighted distinct movement patterns; findings suggest that while the mice display key TD traits, the effects can differ based on sex.
Article Synopsis
- Tourette disorder (TD) affects 1 in 160 children, but understanding is limited due to inadequate animal models; researchers used CRISPR/Cas9 to create mice with mutations similar to human TD genes.
- The generated mice displayed behaviors like cognitive issues and sensorimotor gating deficits, with these traits being more pronounced in females, despite TD being more common in males.
- The findings suggest that TD-like behaviors in these mouse models are influenced by sex and can be treated with aripiprazole, highlighting the potential for these models in future research on TD.
