Continuous non-invasive ophthalmic glucose sensor for diabetics.

A contact lens with an embedded glucose sensor hologram has been developed for continuous noninvasive monitoring of glucose levels in diabetics. This article describes the development and initial clinical testing of this ophthalmic glucose sensor and provides a comparison to current continuous glucose monitors.

Initial clinical testing of a holographic non-invasive contact lens glucose sensor.

Introduction: The purpose of the present study was to determine the effectiveness of a new holographic contact lens glucose sensor for the non-invasive monitoring of blood glucose.

Methods: One fasting normal subject was given an oral challenge consisting of 44 g of glucose. The contact lens hologram signal and fingerstick blood glucose were measured over a 26- min period.

Holographic glucose sensors.

A novel holographic sensor system capable of detecting dynamic changes in glucose concentration has been developed. The hologram is recorded within a bio-compatible hydrogel matrix containing phenylboronic acid derivatives. On binding glucose, the colour of the hologram red-shifts to longer wavelengths as the hydrogel expands and this colour change is used to quantify glucose concentration.