[(2S,5R)-1-Methyl-5-phenyl-pyrrolidin-2-yl]diphenyl-methanol.

In the title compound, C(24)H(25)NO, the phenyl and diphenyl-methanol substituents are syn to each other. The pyrrolidine ring has an envelope conformation with the flap atom being the C atom bearing the phenyl substituent. The hy-droxy group forms an intra-molecular hydrogen bond with the pyrrolidine N atom, and the phenyl rings lie to same side of the mol-ecule.

Highly regio- and stereoselective Heck reaction of allylic esters with arenediazonium salts: application to the synthesis of kavalactones.

A highly efficient palladium-catalyzed Heck reaction of allylic esters with arenediazonium salts is described. The reaction proceeds under mild conditions, with excellent to total regio- and stereochemical control and with retention of the traditional leaving group. Furthermore, the generality of the present methodology is illustrated by the short total synthesis of the natural kavalactones, yangonine, (+/-)-methysticin, and (+/-)-dihydromethysticin.

Highly stereoselective one-pot procedure to prepare bis- and tris-chalcogenide alkenes via addition of disulfides and diselenides to terminal alkynes.

We present here the reaction of diorganoyl dichalcogenides with terminal alkynes under catalyst-free conditions, by a one-pot procedure, to prepare bis- and tris-chalcogenide alkenes selectively, avoiding the previous preparation of chalcogen alkynes. The reaction proceeded cleanly under mild reaction conditions, and the addition of dichalcogenides to alkynes occurred stereoselectively to give exclusively the corresponding Z isomers. We observed that the selectivity control was governed by the effective participation of the hydroxyl group from propargyl alcohols.

Protective effect of diphenyl diselenide on acute liver damage induced by 2-nitropropane in rats.

The effect of diphenyl diselenide, (PhSe)2, administration on 2-nitropropane (2-NP)-induced hepatic damage was examined in male rats. Rats were pre-treated with a single dose of diphenyl diselenide (10, 50 or 100 micromol/kg). Afterward, they received only one dose of 2-NP (100 mg/kg body weight dissolved in olive oil).

Hydrotelluration of aminoalkynes.

Metal tellurolates (M = B3+; BuTeTeBu/NaBH4/EtOH; Li3+, Te0/BuLi/THF; In3+, BuTeTeBu/InI/EtOH) react with aminoalkynes to produce vinylic tellurides containing amino groups; the regio-, and stereo-chemistry of the hydrotelluration reaction depend on the metallic counter ion and on the nature of the amino group substituent.