Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole.

Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.

Solubility, lipophilicity and membrane permeability of some fluoroquinolone antimicrobials.

Aqueous solubility and distribution of ciprofloxacin, enrofloxacin, norfloxacin and levofloxacin antimicrobials drugs in octanol/buffer system has been measured by the isothermal saturation method using buffer solutions pH2.0 and 7.4 in the temperature range of 293.

Synthesis, biological activity, distribution and membrane permeability of novel spiro-thiazines as potent neuroprotectors.

New spiro-derivatives of 1,3-thiazine - potential neuroprotectors have been synthesized. It has been determined that the obtained compounds are biologically active and capable of blocking the glutamate-induced calcium ion uptake into synaptosomes of rat brain cortex. The inhibitory activity of the test substances was shown to depend on the chemical nature and structure of the substituents bound with an exocyclic nitrogen atom.

Thermodynamics of sorption in the binary liquid crystalline system composed of the poly(propyleneimine) dendrimer and p-n-pentyloxy-p'-cyanobyphenyl by inverse gas chromatography.

A binary system composed of the liquid crystalline poly(propyleneimine) dendrimer and nematic p-n-pentyloxy-p'-cyanobyphenyl has been studied by thermomicroscopy, scanning calorimetry, and inverse gas chromatography. In this system, there is the columnar phase being stable within broad ranges of temperature and component ratio. Dependences of the retention volumes of various solutes, namely, hydrocarbons, alcohols, and amines, on composition of the sorbents are revealed to exhibit the maximum.