Publications by authors named "Angelica Lehker"
Novel Therapies for Nonalcoholic Steatohepatitis (NASH) and Cardiovascular Risk Reduction.
Cardiovasc Hematol Disord Drug Targets
November 2024
Nonalcoholic steatohepatitis (NASH) is a type of nonalcoholic fatty liver disease (NAFLD) characterized by hepatocyte injury and inflammation, in addition to only the presence of steatosis NAFLD. We review the existing data on available novel therapies for NASH and NAFLD and also discuss several therapies in development. We assessed therapies for NASH by searching the databases of PubMed, EMBASE, and Web of Science (SCI) from their inception dates until September 15, 2024.
View Article and Find Full Text PDFArticle Synopsis
- Cryoglobulinemia is a rare condition caused by immune complexes in the blood, leading to symptoms like skin rashes, muscle weakness, and joint pain, particularly in those with mixed forms related to rheumatoid factors.
- Historically, Hepatitis C was a common trigger for mixed cryoglobulinemia, but the advent of direct-acting antivirals has shifted the focus to autoimmune disorders as key causes.
- A case study of a 67-year-old woman with a history of Hepatitis C showed how she presented with septic shock and joint pain, ultimately diagnosed with mixed cryoglobulinemia, highlighting the need for awareness in such patients and the benefits of treating Hepatitis C with DAAs for both viral clearance and symptom
The success of a PCI is best defined by three related components: post-procedure angiographic outcomes, procedural events, and longer-term clinical outcomes. Stenting of long and complex lesions is associated with higher risk of stent thrombosis and restenosis even at long term follow-up. Tapered lesions (i.
View Article and Find Full Text PDFThere is considerable evidence that patients with inflammatory conditions are at higher risk of developing cardiovascular (CV) disease including carotid artery stenosis. CV disease accounts for 35-50% of the excess mortality in patients with inflammatory diseases such as rheumatoid arthritis, with cerebrovascular disease being the second leading cause of death. We review current evidence regarding the association of inflammatory conditions and specifically carotid artery disease.
View Article and Find Full Text PDFBackground: Heart failure is a major cause of morbidity and mortality globally. By the end of this decade, ~8 million Americans will have heart failure with an expenditure of $69.8 billion.
View Article and Find Full Text PDFPurpose Of Review: Acute coronary syndrome is a major health problem affecting ~ 1.5 million individuals a year in the USA. We review the contemporary role of anti-anginal and anti-ischemic therapies in the management of an individual presenting with an acute coronary syndrome.
View Article and Find Full Text PDFThe association between the presence of coronary artery calcium (CAC) and the risk of coronary artery disease (CAD) has been appreciated for decades. In this review, we critically appraise the role of CAC based on computerized tomography in contemporary risk stratification. Available evidence suggests that the measurement of CAC is a useful modality in many patients for more precise risk stratification and prognostic determination.
View Article and Find Full Text PDFBackground: This study aimed to compare the effect of using versus not using the Rapid-Shallow Breathing Index (RSBI) as a readiness criterion for Spontaneous Breathing Trials (SBT) on SBT success.
Materials And Methods: Daily readiness screens were performed within a respiratory therapist-driven weaning protocol. Patients who passed these screens underwent a one-time measurement of the RSBI and then a SBT regardless of RSBI result.