Publications by authors named "Angelica Lam"

Protein function is canonically believed to be more conserved than amino acid sequence, but this idea is only well supported in folded domains, where highly diverged sequences can fold into equivalent 3D structures. In contrast, intrinsically disordered protein regions (IDRs) do not fold into a stable 3D structure, thus it remains unknown when and how function is conserved for IDRs that experience rapid amino acid sequence divergence. As a model system for studying the evolution of IDRs, we examined transcriptional activation domains, the regions of transcription factors that bind to coactivator complexes.

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Article Synopsis
  • Gene expression in Arabidopsis is regulated by over 1,900 transcription factors (TFs), with many lacking known activation domains (ADs), which are crucial for their function.
  • Researchers used a yeast library approach to identify and annotate 1,553 previously unknown ADs, discovering that more than half of the Arabidopsis TFs possess these domains.
  • They developed a neural network model to predict ADs and their necessary sequence features, revealing six distinct feature combinations linked to activation, and confirmed conserved AD positioning in the AUXIN RESPONSE FACTOR family of TFs.
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