Publications by authors named "Angelica Engvall"
Context: There is a lack of reliable biomarkers capable of predicting postoperative tumor progression of nonfunctioning pituitary adenomas (NFPAs).
Objective: To discover proteomic profiles associated with postoperative tumor progression in patients with NFPAs. This was a case-controlled exploratory study at a tertiary university hospital.
Article Synopsis
- The study investigated DNA methylation patterns in patients with nonfunctioning pituitary adenomas (NFPA) to identify early biomarkers of tumor progression.
- Researchers compared tumor samples from patients who needed reoperation due to tumor progression with those whose tumors remained stable for at least 5 years.
- They found significant differences in DNA methylation at 605 specific CpG positions related to 389 genes, suggesting potential epigenetic markers that could predict future tumor progression.
Objective: Current markers predicting tumour progression of pituitary adenomas after surgery are insufficient. Our objective was to investigate if minichromosome maintenance protein 7 (MCM7) expression predicts tumour progression in non-functioning pituitary adenomas (NFPAs).
Methods: In a cohort study of surgically treated NFPAs, two groups with distinctly different behaviour of a residual tumour were selected: one group requiring reintervention due to tumour progression (reintervention group, n = 57) and one with residual tumours without progression (radiologically stable group, n = 40).