Publications by authors named "Angelica B Barbezan"

Nanotechnology has revolutionized medicine, especially in oncological treatments. Gold nanoparticles (AuNPs) stand out as an innovative alternative due to their biocompatibility, potential for surface modification, and effectiveness in radiotherapeutic techniques. Given that prostate cancer ranks as one of the leading malignancies among men, there's a pressing need to investigate new therapeutic approaches.

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Article Synopsis
  • The study assessed two radioimmunoconjugates, In-DTPA-trastuzumab and Lu-DOTA-trastuzumab, focusing on how different chelating agents affect their properties and binding to HER2 tumor cells.
  • Despite the variations in chelating agents, the molar ratios (1:10 and 1:20) did not compromise the integrity, labeling process, or stability of the antibodies.
  • However, notable differences were found in the lipophilicity and binding efficiency to HER2 positive SK-BR-3 cells, indicating that selecting the right chelating agent and ratio is crucial for developing effective radioimmunoconjugates.
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Early and accurate detection of primary or metastatic tumors is of great value in staging, treatment management, and prognosis. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of solid cancers, and so, is a promising approach for tumor imaging. The GX1 (CGNSNPKSC) peptide was identified by phage display library and has been investigated as a marker for human cancers.

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Food irradiation is an effective and safe method for preservation and long-term storage, and it is approved for use in over 60 countries for various applications in a wide variety of food products. This process is performed by use of accelerated electron beams, X-rays, or gamma radiation ( Co or Cs). 2-Alkylcyclobutanones (2-ACBs) are the only known radiolytic products generated from foods that have fatty acids (triglycerides) and are subjected to irradiation.

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