Design and adaptation of miniaturized electrochemical devices integrating carbon nanotube-based sensors to commercial CE equipment.

The design of new electrochemical devices integrating carbon nanotube sensors and their adaptation to commercial CE equipments are described. One of these designs was made for using commercial screen-printed electrodes, whereas the second was projected for coupling commercial glassy carbon electrodes. The electrochemical characterization of these devices revealed that their hydrodynamic behaviour is strongly influenced by the electrode modification with multi-wall carbon nanotubes that provided faster and/or more sensitive signals.

Ethylglucuronide determination in urine and hair from alcohol withdrawal patients.

Two methods for the determination of ethylglucuronide (EtG) in urine and in hair have been developed by liquid chromatography- tandem mass spectrometry. These two methods were fully validated, including linearity (0.25-100 microg/mL in urine; 0.

A novel indazolo-triazolo-benzotriazepine exerts anti-inflammatory effects by inhibition of cyclooxygenase-2 activity and nitric oxide synthase-2 expression.

We have studied the anti-inflammatory activity of (6-(p-bromophenyl)amino-7-(p-chlorophenyl)indazolo[2',3':1,5]-1,2,4-triazolo[4,3-a]-1,3,5-benzotriazepine (ITB), prepared by solid-phase synthesis. This novel compound reduced the production of nitrite and PGE(2) in RAW 264.7 macrophages stimulated with lipopolysaccharide in a concentration-dependent manner.