Publications by authors named "Angeles Domiguez-Soto"
Article Synopsis
- Vitamin B9, or folate, is crucial for one-carbon metabolism and is taken into cells through specialized transporters that vary in type and expression based on cell type.
- The study highlights that M2 macrophages accumulate more 5-MTHF, the main serum folate form, compared to M1 macrophages due to differences in transporter expression, with M1 favoring RFC and M2 favoring FRβ and PCFT.
- Activin A plays a significant role in regulating these transporters in macrophages by altering their expression and affecting folate uptake, indicating the importance of macrophage polarization in folate metabolism.
