Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis.

Neurodevelopmental disorders are associated with metabolic pathway imbalances; however, most metabolic measurements are made peripherally, leaving central metabolic disturbances under-investigated. Cerebrospinal fluid obtained intraoperatively from children with autism spectrum disorder (ASD, = 34), developmental delays (DD, = 20), and those without known DD/ASD ( = 34) was analyzed using large-scale targeted mass spectrometry. Eighteen also had epilepsy (EPI).