Publications by authors named "Angelakis Leonidas"

Sestrins (Sesns) are a family of highly conserved stress-inducible proteins and various stresses have been shown to strongly up-regulate them. Sestrin 2 (Sesn2) deficiency has been shown to partially suppress pulmonary emphysema. The aim of this study was to evaluate Sesn2 levels in COPD patients and its possible associations with the presence of emphysema and blood eosinophils.

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Article Synopsis
  • Hemoptysis, a common symptom indicating bleeding in the respiratory tract, often presents diagnostic challenges in clinical settings, particularly when bronchoscopy fails to identify the cause.
  • This article discusses cases of hemoptysis that occurred after angiographic procedures in thoracic vessels, noting that key findings like localized hyperemia and vascular dilatations in the bronchial mucosa provided crucial insights for diagnosis.
  • The authors propose potential underlying mechanisms for these vascular abnormalities and review existing literature on similar clinical cases to enhance understanding and management of hemoptysis.
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Sputum and blood eosinophils are proposed as candidate biomarkers for the identification of chronic obstructive pulmonary disease (COPD) patients at risk for exacerbation and treatment response. In this study, we evaluated the associations of eosinophils with the presence of emphysema in COPD patients. Induced sputum and blood eosinophil measurements were performed in consecutive COPD patients.

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