Publications by authors named "Angela Yang Liu"
J Pharm Biomed Anal
March 2018
Article Synopsis
- A calibration model was developed for in-line quantification of active pharmaceutical ingredients (API) using near infrared (NIR) spectroscopy during tablet production, optimizing the measurement setup and investigating the impact of feed frame filling on NIR spectra.
- The model was validated through accuracy profiling and measurement uncertainty assessment, implementing an NIR probe in a rotary tablet press to monitor different API concentrations and improve signal quality with notched paddle wheel fingers.
- Various calibration models were compared, with partial least squares (PLS) regression yielding the best predictive performance for determining API content based on validation experiments.
