Efficacy and task structure of bimanual training post stroke: a systematic review.

Background: Bimanual training has been shown to be as effective as, but not superior to, unimanual paretic upper extremity (UE) training interventions in improving paretic UE function and use post stroke. However, it is still unclear whether different training interventions or task structures within bimanual interventions may differentially affect the outcomes.

Objective: The objectives of this review were to (1) systematically determine the efficacy of bimanual training in relation to the International Classification of Functioning, Disability and Health model components and (2) explore the structure of current bimanual training interventions.

The effectiveness of physical therapist-administered group-based exercise on fall prevention: a systematic review of randomized controlled trials.

Background: Falls are a verified cause of morbidity and mortality in adults older than 65 years. Exercise under the direction of a physical therapist has been shown to reduce the risk of falls in older adults; however, it is not clear whether physical therapist-directed group-based exercise could produce similar results.

Purpose: The purpose of this systematic review was to summarize the evidence on the effectiveness of physical therapist-administered group-based exercise when compared with various controls for falls prevention and improvement of quality of life.

Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii.

Background: Geldanamycin (GA), a benzoquinone ansamycin antibiotic has been shown in vitro to possess anti-plasmodial activity. Pharmacological activity of this drug is attributed to its ability to inhibit PfHSP90. The parasite growth arrest has been shown to be due to drug-induced blockage of the transition from ring to trophozoite stage.

Preventing child abuse and neglect: a national evaluation of Parents Anonymous groups.

This evaluation assessed whether participation in Parents Anonymous mutual support groups was associated with child maltreatment prevention. Parents new to groups across the United States were interviewed at baseline, one month, and six months. Using standardized scales, all parents showed improvements in some child maltreatment outcomes, risk factors, and protective factors.

The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates.

Herkinorin is the first mu-opioid receptor-selective ligand from the salvinorin A diterpenoid scaffold. Herkinorin has relative mu > kappa > delta binding selectivity, and it can act as an agonist at both mu- and kappa-receptors, in vitro. These studies were the first in vivo evaluation of the effects of herkinorin in nonhuman primates, using prolactin release, a neuroendocrine biomarker assay that is responsive to both mu- and kappa-agonists, as well as to compounds with limited ability to cross the blood-brain barrier.

The development of in-group favoritism: between social reality and group identity.

This study examined how social reality restricts children's tendency for in-group favoritism in group evaluations. Children were faced with social reality considerations and with group identity concerns. Using short stories, in this experimental study, conducted among 3 age groups (6-, 8-, and 10-year-olds), the authors examined the trait attribution effects of reality constraints on eye-color differences and national group differences.

Multiple opportunistic infections after high-dose steroid therapy for giant cell arteritis in a patient previously treated with a purine analog.

We present the case of a 74-y-old HIV-negative female who suffered simultaneously from multiple opportunistic infections and a Klebsiella pneumoniae sepsis during high-dose steroids for giant cell arteritis. The patient was treated with a purine analog due to hairy cell leukaemia 10 y previously. Purine analog therapy can lead to long lasting defects in cell-mediated immunity.