Publications by authors named "Angela W Nieh"
Article Synopsis
- Various genetic techniques help trace cell lineage during tissue development, with some focusing on spatial/temporal aspects and others linking gene expression to lineage.
- The G-TRACE system allows for quick visualization of GAL4 expression patterns, enabling genome-wide expression-based lineage studies conducted by UCLA students and high school scholars.
- Findings revealed new expression-based lineage patterns and were compiled into the G-TRACE Expression Database (GED), contributing to better student learning outcomes and retention in STEM fields.
Bacteriophage BPP-1 infects and kills Bordetella species that cause whooping cough. Its diversity-generating retroelement (DGR) provides a naturally occurring phage-display system, but engineering efforts are hampered without atomic structures. Here, we report a cryo electron microscopy structure of the BPP-1 head at 3.
View Article and Find Full Text PDFDiversity-generating retroelements (DGRs) are in vivo sequence diversification machines that are widely distributed in bacterial, phage, and plasmid genomes. They function to introduce vast amounts of targeted diversity into protein-encoding DNA sequences via mutagenic homing. Adenine residues are converted to random nucleotides in a retrotransposition process from a donor template repeat (TR) to a recipient variable repeat (VR).
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