Publications by authors named "Angela Turrero"
The Kirsten Rat Sarcoma Virus (KRAS) oncoprotein, one of the most prevalent mutations in cancer, has been deemed undruggable for decades. The hypothesis of this work was that delivering anti-KRAS monoclonal antibody (mAb) at the intracellular level could effectively target the KRAS oncoprotein. To reach this goal, we designed and developed tLyP1-targeted palmitoyl hyaluronate (HAC16)-based nanoassemblies (HANAs) adapted for the association of bevacizumab as a model mAb.
View Article and Find Full Text PDFIntroduction: Glioblastomas present intensive angiogenesis, thus anti-Vascular Endothelial Growth Factor (VEGF) antibodies (mAbs) have been proposed as promising therapies. However, the results of clinical trials reported moderate toxicity and limited effectiveness. This study evaluates the in vivo pharmacokinetics and biodistribution of these mAbs in a growing model of glioblastoma in rats using Positron Emission Tomography (PET).
View Article and Find Full Text PDFArticle Synopsis
- Spinal cord injury (SCI) leads to long-term neurological and systemic issues, including autoimmunity that affects recovery.
- Researchers found that autoantibodies, which increase one month after SCI, were already present in healthy individuals and target unusual proteins in the spinal cord.
- The study identified 16 specific self-antigens related to changes following SCI, suggesting that these autoantibodies could explain the development of autoimmunity and pinpoint new areas for future research.