CHIP away at the marrow-clot connection: inflammation, clonal hematopoiesis, and thromboembolic disease.

Both the incidence and prognosis of arterial atherothrombosis and venous thromboembolism are strongly correlated with increasing age. Over the past decade, clonal hematopoiesis of indeterminate potential (CHIP) has been identified as a novel biomarker for cardiovascular disease. Driven by somatic mutations in the hematopoietic system, the epidemiology of CHIP is highly age-dependent: among individuals aged ≥70 years in the general population, estimated prevalence of CHIP exceeds 10%.