Publications by authors named "Angela Tata"
Article Synopsis
- Checkpoint blockade therapy is a promising cancer treatment, but not all patients benefit, highlighting the need for new targets.
- Blocking the KLRG1 receptor improves anti-tumor responses from NK cells and CD8 T cells, significantly reducing melanoma and breast cancer growth in mice.
- Combining KLRG1 blockade with PD-1 therapy enhances treatment effectiveness, leading to reduced tumor size and increased immune cell activation, even in tumors resistant to PD-1 therapy.
The liver harbors two main innate lymphoid cell (ILC) populations: conventional NK (cNK) cells and tissue-resident NK (trNK) cells. Using the MCMV model of infection, we find that, in contrast to liver cNK cells, trNK cells initially undergo a contraction phase followed by a recovery phase to homeostatic levels. The contraction is MCMV independent because a similar phenotype is observed following poly(I:C)/CpG or α-GalCer injection.
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