Publications by authors named "Angela Taravella Oill"
Article Synopsis
- Pediatric brain tumor prognosis is currently poor, but there is hope that CAR T cell therapy could improve outcomes, as indicated by a study involving the first six treated patients in a clinical trial (NCT04510051).
- Interim results show that three out of five evaluable patients experienced some temporary clinical benefits, while overall there were no serious side effects from the treatment, despite some patients experiencing common issues like cytopenias.
- Analysis of immune responses revealed interesting interactions between CAR T cells and the patient's immune system, highlighting differences in T cell populations in the cerebrospinal fluid compared to peripheral blood, suggesting the need for careful sampling in future studies.
The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure that includes long palindromes, tandem repeats and segmental duplications. As a result, more than half of the Y chromosome is missing from the GRCh38 reference sequence and it remains the last human chromosome to be finished. Here, the Telomere-to-Telomere (T2T) consortium presents the complete 62,460,029-base-pair sequence of a human Y chromosome from the HG002 genome (T2T-Y) that corrects multiple errors in GRCh38-Y and adds over 30 million base pairs of sequence to the reference, showing the complete ampliconic structures of gene families TSPY, DAZ and RBMY; 41 additional protein-coding genes, mostly from the TSPY family; and an alternating pattern of human satellite 1 and 3 blocks in the heterochromatic Yq12 region.
View Article and Find Full Text PDFObjectives: The aim of this study was to characterize the genetic relationships within and among four neighboring ethnolinguistic groups in northern Kenya in light of cultural relationships to understand the extent to which geography and culture shape patterns of genetic variation.
Materials And Methods: We collected DNA and demographic information pertaining to aspects of social identity and heritage from 572 individuals across the Turkana, Samburu, Waso Borana, and Rendille of northern Kenya. We sampled individuals across a total of nine clans from these four groups and, additionally, three territorial sections within the Turkana and successfully genotyped 376 individuals.
Background: Neanderthal introgressed DNA has been linked to different normal and disease traits including immunity and metabolism-two important functions that are altered in liver cancer. However, there is limited understanding of the relationship between Neanderthal introgression and liver cancer risk. The aim of this study was to investigate the relationship between Neanderthal introgression and liver cancer risk.
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