Publications by authors named "Angela Ploysangngam"
Article Synopsis
- Myosin-binding protein H (MyBP-H) is similar to MyBP-C and is found in skeletal muscle but has an unclear function, particularly in adult fast-twitch muscle.
- Research indicates that MyBP-H is highly expressed in prenatal rat fast-twitch muscles and larval zebrafish, hinting at its role in muscle development, which is being further investigated.
- While MyBP-H lacks key domains found in MyBP-C that modulate muscle contractility, experiments show it may function similarly by acting as a molecular "brake," raising new questions about muscle development roles.
Myosin-binding protein H (MyBP-H) is a component of the vertebrate skeletal muscle sarcomere with sequence and domain homology to myosin-binding protein C (MyBP-C). Whereas skeletal muscle isoforms of MyBP-C (fMyBP-C, sMyBP-C) modulate muscle contractility via interactions with actin thin filaments and myosin motors within the muscle sarcomere "C-zone," MyBP-H has no known function. This is in part due to MyBP-H having limited expression in adult fast-twitch muscle and no known involvement in muscle disease.
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