Publications by authors named "Angela Peterson"

Article Synopsis
  • Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive cancer where many patients experience treatment-resistant recurrent or metastatic disease.
  • A case study of a 48-year-old woman with HRAS G12S mutated HNSCC showed that treatment with tipifarnib, a farnesyltransferase inhibitor, led to an impressive 8-month partial response, despite her previous lack of success with other therapies.
  • The research indicates that while tipifarnib is promising, resistance may arise through the activation of the AKT pathway, suggesting that combining tipifarnib with a PI3K inhibitor could enhance treatment effectiveness in HRAS-mutated HNSCC.
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The Irano-Turanian (IT) floristic region is considered an important center of origin for many taxa. However, there is a lack of studies dealing with typical IT genera that also occur in neighboring areas. The species-rich monocot genus Salisb.

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The internal transcribed spacer (ITS) region (ITS1, 5.8S rDNA, ITS2) represents the most widely applied nuclear marker in eukaryotic phylogenetics. Although this region has been assumed to evolve in concert, the number of investigations revealing high degrees of intra-individual polymorphism connected with the presence of pseudogenes has risen.

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Our study represents the first phylogenetic analyses of the genus Gagea Salisb. (Liliaceae), including 58 species of Gagea and 6 species of the closely related genus Lloydia Salisb. ex Rchb.

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Molecular studies of 21 species of the large Cactaceae genus Mammillaria representing a variety of intrageneric taxonomic levels revealed a high degree of intra-individual polymorphism of the internal transcribed spacer region (ITS1, 5.8S rDNA, ITS2). Only a few of these ITS copies belong to apparently functional genes, whereas most are probably non-functional (pseudogenes).

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