Mechanistic variations in ionic hydrogenation of unsaturated phosphine and amine boranes.

Internal hydride transfer occurs when tethered carbocations are generated from unsaturated phosphine or phosphinite boranes. 3-Methylenecyclohexyl-derived boranes 12 or 18 react with MsOH to give ionic hydrogenation products with high syn-selectivity. With unsaturated amine boranes, initial hydrogen evolution gives BH(2)(OMs) complexes, but IH occurs using excess MsOH in a slower second stage.

Impact of vitamin C on endothelial function and exercise capacity in patients with a Fontan circulation.

Objective:   To evaluate the impact of antioxidant therapy on functional health status in Fontan-palliated patients. Design.  Prospective, randomized, double-blind, placebo-controlled trial.

Usefulness of peripheral vascular function to predict functional health status in patients with Fontan circulation.

After the Fontan operation, patients are at a substantial risk of the development of impaired functional health status. Few early markers of suboptimal outcomes have been identified. We sought to assess the association between peripheral vascular function and functional health status in Fontan-palliated patients.