Association of complex lipids containing gangliosides with cognitive development of 6-month-old infants.

Background: Human breastmilk contains gangliosides which may play an important role in infant neurodevelopment.

Aim: A pilot study was conducted to assess the impact of infant formula supplemented with gangliosides from complex milk lipid on cognitive functions of normal healthy infants.

Study Design: The study was a double-blind, randomized, controlled, parallel group clinical trial in which infants received the treatment or control product from 2 to 8 weeks of age until 24 weeks of age.

The safety of New Zealand bovine colostrum: nutritional and physiological evaluation in rats.

The potential detrimental effects of two different oral doses of bovine colostrum were assessed in young rats according to OECD guidelines. Colostrum was supplemented at 3% and 10% into a normal rat chow. A control group received the rat chow with no supplementation.

Dietary peptides increase endogenous amino acid losses from the gut in adults.

Background: Accurate estimates of endogenous ileal total nitrogen and amino acid flows are necessary to ascertain true dietary amino acid digestibility coefficients and for the factorial estimation of dietary amino acid requirements.

Objective: The objective was to ascertain endogenous amino acid losses from the small bowel in human subjects consuming a protein-free diet or a diet with enzyme-hydrolyzed casein (EHC; MW <5000) as the sole source of nitrogen.

Design: The subjects were 8 men and women with terminal ileum ileostomies after ulcerative colitis who consumed the protein-free and EHC-based diets in a crossover design.

An acute ileal amino acid digestibility assay is a valid procedure for use in human ileostomates.

An acute (24-h) feeding/digesta sampling procedure was evaluated in a preliminary study using growing pigs. The validated acute procedure was then applied using human ileostomates to determine apparent and true ileal amino acid digestibilities of 4 dietary protein sources. The acute method involved feeding ileostomized pigs a single meal containing the test protein as part of a purified diet, with no previous dietary adaptation, followed by an 8-h collection of digesta.