Publications by authors named "Angela Lopez Garcia"

Article Synopsis
  • CMV-seropositive kidney transplant recipients (KTRs) with immune protection can still experience CMV infections, prompting researchers to explore potential biomarkers for identifying those at risk.
  • Whole blood miRNA sequencing was conducted, revealing that hsa-miR-125a-5p levels were significantly lower in KTRs who developed CMV viremia within 90 days.
  • hsa-miR-125a-5p may be useful as a biomarker for assessing the risk of CMV reactivation in KTRs, despite the presence of detectable CMV-specific immune responses.
View Article and Find Full Text PDF

is a food-borne pathogen often linked to poultry sources, causing gastrointestinal infections in humans, with the numbers of multidrug resistant (MDR) isolates increasing globally. To gain insight into the genomic diversity of common serovars and their potential contribution to disease, we characterized antimicrobial resistance genes, and virulence factors encoded in 88 UK and 55 Thai isolates from poultry; the presence of virulence genes was detected through an extensive virulence determinants database compiled in this study. Long-read sequencing of three MDR isolates, each from a different serovar, was used to explore the links between virulence and resistance.

View Article and Find Full Text PDF

Acute non-typhoidal salmonellosis (NTS) caused by a Gram-negative bacterium serovar Typhimurium ( Tm) is one of the most common bacterial foodborne diseases worldwide. Bacteriophages (phages) can specifically target and lyse their host bacteria, including the multidrug-resistant strains, without collateral damage to other bacteria in the community. However, the therapeutic use of phages is still poorly investigated.

View Article and Find Full Text PDF

Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen species (ROS) is an essential component of these responses. We showed previously that ectopic expression of the heme-containing catalase enzyme in Candida albicans enhances resistance to oxidative stress, combinatorial oxidative plus cationic stress, and phagocytic killing.

View Article and Find Full Text PDF