A gene expression resource generated by genome-wide lacZ profiling in the mouse.

Knowledge of the expression profile of a gene is a critical piece of information required to build an understanding of the normal and essential functions of that gene and any role it may play in the development or progression of disease. High-throughput, large-scale efforts are on-going internationally to characterise reporter-tagged knockout mouse lines. As part of that effort, we report an open access adult mouse expression resource, in which the expression profile of 424 genes has been assessed in up to 47 different organs, tissues and sub-structures using a lacZ reporter gene.

Maternal response to high-risk obstetric telemedicine consults when perinatal prognosis is poor.

This is a qualitative descriptive study evaluating the maternal response after the woman has learned her pregnancy has a poor prognosis via telemedicine rather than in a traditional, face-to-face, consultation method. In general, telemedicine was positively viewed by the participants; however, the experience may be markedly improved by implementing several simple changes in the overall consultative process.

Geographic variability in human papillomavirus vaccination among U.S. young women.

Background: Little information is available on geographic disparity of human papillomavirus (HPV) vaccination among women aged 18-26 years in the U.S. Genital HPV is the most common sexually transmitted infection in the U.

Challenges of implementation of a web-camera system in the neonatal intensive care unit.

Over the past ten years, web-cameras often have been used in the NICU to support parents and connect families with their hospitalized neonate. This article describes the history of images and video use in the NICU to aid in linking parents and then focuses on the challenges and lessons learned through redesign, installation, and management of a new web-camera system. Technology can support NICU families, and when implemented with input from nurses and families, the process can be a positive experience.

Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.

Coordination of cellular processes through the establishment of tissue-specific gene expression programs is essential for lineage maturation. The basic helix-loop-helix hemopoietic transcriptional regulator TAL1 (formerly SCL) is required for terminal differentiation of red blood cells. To gain insight into TAL1 function and mechanisms of action in erythropoiesis, we performed ChIP-sequencing and gene expression analyses from primary fetal liver erythroid cells.

Comparing parents' and children's views of children's quality of life after heart transplant.

Purpose: The purpose of this focused ethnographic study was to explore the quality of life (QOL) of school-age heart-transplant recipients.

Design And Methods: Semistructured interviews were conducted with 11 parent-child dyads. Data were analyzed using content analysis and constant comparison.