Publications by authors named "Angela L A Puchlopek-Dermenci"
The first enantioselective total synthesis of the epipolythiodiketopiperazine (ETP) natural product (-)-acetylapoaranotin (3) is reported. The concise synthesis was enabled by an eight-step synthesis of a key cyclohexadienol-containing amino ester building block. The absolute stereochemistry of both amino ester building blocks used in the synthesis is set through catalytic asymmetric (1,3)-dipolar cycloaddition reactions.
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- The synthesis of a smoothened receptor inhibitor is achieved using an efficient, five-step process.
- Key to this method is an enzymatic transamination combined with dynamic kinetic resolution, creating two stereogenic centers in one step.
- The final product, an anti amine, is produced with a high diastereomeric ratio (>10:1) and excellent enantiomeric excess (>99%), yielding a 40% overall yield.