Graph-theoretical analyses have been previously used to investigate changes in the functional connectome in patients with Alzheimer's disease (AD). However, these analyses generally assume static organizational principles, thereby neglecting a fundamental reconfiguration of functional connections in the face of neurodegeneration. Here, we focus on differences in the community structure of the functional connectome in young and old individuals and patients with AD.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
March 2011
We investigate on the use of the Domain Embedding Method (DEM) for the forward modelling in EIT. This approach is suitably configured to overcome the model meshing bottleneck since it does not require that the mesh on the domain is adapted to the boundary surface. This is of crucial importance for, e.
View Article and Find Full Text PDFIEEE Trans Image Process
June 2006
A coarse-to-fine data fitting algorithm for irregularly spaced data based on boundary-adapted adaptive tensor-product semi-orthogonal spline-wavelets has been proposed in Castaño and Kunoth, 2003. This method has been extended in Castaño and Kunoth, 2005 to include regularization in terms of Sobolev and Besov norms. In this paper, we develop within this least-squares approach some statistical robust estimators to handle outliers in the data.
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